- Both sets of his grandparents came from Salonika in northern Greece.
- He based his character in The Birdcage (1996) (a flamboyantly, almost over-exaggeratedly feminine homosexual house servant) on his grandmother, in particular his character's speech.
- Based the voice of Moe the bartender (Les Simpson (1989)) on actor Al Pacino.
- He is close friends with actor Matthew Perry.
- Based the voice of quack Dr. Nick Rivera (in Les Simpson (1989)) on actor Desi Arnaz.
- He has estimated that he has done "literally 100, 150 different characters' voices" on The Simpsons (1989) (TV).
- Attended college with Oliver Platt; attended acting school with Sharon Stone.
- Based the voice of Comic Book Guy (in Les Simpson (1989)) on his college roommate.
- Based the voice of Lou the Cop (in Les Simpson (1989)) on actor Sylvester Stallone.
- Based the voice of Chief Wiggum (in Les Simpson (1989)) on actor Edward G. Robinson.
- His family is of Sephardic Jewish background.
- Has a son named Hal Azaria (b. June 6, 2009) with girlfriend Katie Wright.
- Was a camper at the real life Camp Towanda, where the movie Wet Hot American Summer (2001) was filmed.
- Was a bartender in New York at the Arcadia.
- Based the voice of Apu (in Les Simpson (1989)) on the "standard" 7-11 employee and on Peter Sellers's character Hrundi V. Bakshi in La Party (1968).
- Paid exactly $10 million to purchase a seven-bedroom, ten-bath, 8434-square-foot house in Los Angeles's Bel-Air area. He also owns a 1108-square-foot house in the Hollywood Dell area of Los Angeles's Hollywood Hills and a 3320-square-foot house in Beverly Hills. (2009)
- Attended Tufts University in Medford, Massachusetts, from 1981-1985, but did not receive his B.A. until he completed two courses in L.A. in 1987. Tufts awarded him its Light on the Hill Award in 1999.
- A favorite of playwright Jenelle Riley; characters in her shows are frequently hybrids of his name with his Les Simpson (1989) characters (e.g. Hank Wiggum). The lead character in her award-winning film The Perfect Candidate (2004) is named Frank Grimes, after "Homer's Enemy".
- Spent over $300,000 of his own money to make his short film Nobody's Perfect (2004).
- Performing "Sexual Perversity In Chicago" alongside Matthew Perry, Minnie Driver, and Kelly Reilly in London's Comedy Theatre. (juillet 2003)
- Is playing a gay version of Sir Lancelot in the Broadway production of "Spamalot", the musical version of Monty Python : Sacré Graal ! (1975), which opened on Broadway in January of 2005. (février 2005)
- Alumnus of the AADA (American Academy of Dramatic Arts), Class of 1980.
- He and his ex-wife Helen Hunt have both guest-starred on the TV show Friends (1994), though not in the same episode. Paget Brewster, who plays his wife on Huff (2004), also had a recurring role on Friends (1994).
- Life long New York Mets Fan.
- Has been selected to play Sir Lancelot in the Broadway production of "Spamalot", the musical version of Monty Python : Sacré Graal ! (1975), scheduled to open on Broadway in February, 2005. (juillet 2004)
- He is a lifelong Democrat.
- Appeared in two films in 1999 with the word "Mystery" in the title: Mystery, Alaska (1999) and Mystery Men (1999).
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