- McCoy and Timothy Dalton appeared together on stage in London in 1986 and complained to each other that long-term work was so hard to find. The next year, both had screen acting breaks when McCoy was cast as the Seventh Doctor in Docteur Who (1963) and Dalton was cast as James Bond in Tuer n'est pas jouer (1987). However, both McCoy's tenure as the Doctor and Dalton's tenure as Bond proved short-lived as both of these iconic British franchises were cancelled in 1989 for several years and recast when they eventually returned.
- He is the only actor to appear in both Docteur Who (1963) and Le seigneur du temps (1996).
- He became the first of three non-English actors to portray the character of the Doctor and the first of many actors to speak with an accent other than Received Pronunciation English: Christopher Eccleston portrayed the Ninth Doctor in 2005 with a Northern accent, David Tennant is a fellow Scot who portrayed the Doctor from 2005 to 2010 with a London/Estuary accent, Peter Capaldi is likewise Scottish and plays the Twelfth Doctor with his natural accent, and Jodie Whittaker plays the role with her Yorkshire accent.
- He is the the only Doctor to have played the role during two regenerations. When Colin Baker left the role he refused to do the regeneration scene. So Sylvester donned Baker's costume and a blonde wig and stood in as Baker. This is the reason that for only the second time in the series (See Peter Davison's regeneration) the Doctor's face is obscured as he changes his appearance.
- His father Percy Kent-Smith was a Royal Navy submarine officer and was killed in the second world war on July 18, 1943, only a month before he was born.
- He is adept at playing both the xylophone and the spoons. He can also juggle and once gained a reputation for stuffing live ferrets down his trousers.
- He was considered for the role of Bilbo Baggins in Le Seigneur des anneaux : La Communauté de l'anneau (2001), Le Seigneur des anneaux : Les Deux Tours (2002) and Le Seigneur des anneaux : Le Retour du roi (2003). He played Radagast the Brown in Le Hobbit : Un Voyage Inattendu (2012), Le Hobbit : La Désolation de Smaug (2013) and Le Hobbit: La Bataille des Cinq Armées (2014).
- He reportedly took offence to the line written by Mark Gatiss and delivered by David Walliams in the BBC2 sketch The Pitch of Fear (1999) in which Sydney Newman says the Doctor could be played "by any f***** with an Equity Card" towards the end of its run. It was subsequently edited from the version included on a DVD at Gatiss' request. McCoy's acting work has included performances with the Royal Shakespeare Company.
- McCoy technically became the longest-serving Doctor after reprising the role in 1996. His term as the Doctor stretched from 1987 until 1996, a total of 8.5 years. However, as the series was not produced as an ongoing series from the end of Docteur Who (1963) in 1989 until the American co-production Le seigneur du temps (1996), in which McCoy handed over to Paul McGann, Tom Baker is still the longest continuously-serving Doctor on screen at seven years (1974-1981).
- He did not start acting until he was 28 years old.
- The script editor of Doctor Who during the McCoy era, Andrew Cartmel, described McCoy as "the Dark Doctor" because he was characterized as more cunning and manipulative than previous incarnations.
- He was raised primarily in Dublin, Ireland.
- He has two roles in common with John Hurt: (1) Hurt played the Fool in King Lear (1983) while McCoy played him in King Lear (2008) and (2) McCoy played the Seventh Doctor in Docteur Who (1963) and Le seigneur du temps (1996) while Hurt played the War Doctor in Doctor Who (2005).
- He is one of three actors who portrayed The Doctor on TV to appear in an episode of Casualty (1986). The others are Colin Baker and Christopher Eccleston.
- In May 2005, he attended Collectormania 7 at Milton Keynes and was about to begin a stage run in Glasgow.
- Is one of four Scottish born actors to portray the Doctor. The other three being [name=6967441].,the fifteenth Doctor, [name=0134922], the thirteenth Doctor, and [name=0855039[, the eleventh Doctor.
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