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At the Mexican-Guatemalan border, young teenage lovers Sabina and Jovany, both Hondurans, accidentally meet again after some years apart. She plans to get to the United States and dreams about being a great singer; he commits all the required atrocities to be accepted by the gang La Mara Salvatrucha. Sabina and Jovany clash with the most adverse conditions at the border, including white slavery, Mexican and American migratory agents Burrona and Patrick, brothel matron Doña Lita, Don Nico the Mexican Consul in Tecún Umán, the drug-trafficking networks, the army, and La Mara Salvatrucha.

On a lark in Tijuana, a carefree Brazilian art student crosses paths with a brooding Mexican journalist, sparking a cascade of events across both Mexico and Brazil. As Dolores and Damián discover an intimate love and a mysterious spiritual heritage, they struggle with ever more costly choices.