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"Un groupe d'enfants génétiquement améliorés s'échappe d'un projet de laboratoire. Des années plus tard, voici Max, l'un des évadés qui travaille maintenant pour un service de messagerie dans le nord-ouest post-apocalyptique du Pacifique."

12 genetically enhanced childern escape from a military base that created them. 10 years later, after The Pulse, a magnetic bomb that destroyed every computer in USA, has struck, Max Guevara, one of the 12 escapees, is a bike messenger in (what's left of) Seattle and with cyberjournalist, Logan Cale, she tries to rid the world of crime and corruption, avoid her creators and uncover her past.

Lydecker realizes that he has lost control over Manticore, as Madame X is now clearly running the show. He would rather see the project destroyed than see it abused by others. He asks Max for help in bringing Manticore down. Together with Zack and other X5's, they storm the facility and destroy the DNA lab.

Max hires a private detective to help her track down a fellow X-5 called Zack. She is about to receive vital information when the detective is found dead. Back at Logan's place, his ex-wife Valerie shows up unexpectedly with an obvious hidden agenda. Max decides to find out the truth about her.

Logan asks Max to be his date for a cousin's wedding where she meets his snobbish uncle and aunt. She also gets to meet Logan's ex-fiancée. Back at Jam Pony, Normal is taken by the mob when there is a delivery mix-up. Original Cindy and Max decide to help him retrieve the right painting to save their boss' life.

The government sends Ames White to clean up the mess that was Manticore. His mission is to eliminate all evidence of the program's existence. Max feels guilty about this, as she was the one that let the X-series out, and goes back near the facility to help a group of escapees evade death. Lydecker contacts Logan to warn Max to stay away from Manticore when he gets her full DNA analysis.

Now that Lydecker has seen her face, Max is on a Wanted poster all over town for a murder she didn't commit. The temptation of the big reward leads even her own boss, Normal, to give her up to the police. Zack and Logan help her escape to Logan's cabin located outside of Seattle. However, when Max learns that Logan's condition has worsened and that he's undergoing a very dangerous surgery, she risks her life to come to the hospital. Logan has lost a lot of blood and the blood bank runs out of AB negative blood. Max gives Logan a transfusion as she is a universal donor, something Manticore had given her and the rest of her brothers and sisters. The transfusion works but she is soon captured by authority. Just as all hope seems lost, Zack shows up and takes responsibility for the murder. She is freed but he is taken back to Manticore.

It's Halloween. Joshua, seeing people dressed up as monsters, believes it the perfect night for him to experience the outside world. He asks Max but she decides against it, insisting that people will be scared of him. Joshua reluctantly agrees to stay inside while Max prepares to go to a party.

Max and Logan finally find a cure for the genetically engineered virus created by Manticore which only endangers Logan when he has any form of physical contact with Max. However the cure is temporary and lasts only ten hours and fifteen minutes . Meanwhile Seattle is being besieged by a Manticore creation which is preying on humans and it is left to Max to try to save the day.

When Asha's militant group, S1W comes under fire, Max discovers that it is all because of a Manticore strategist - another transgenic called Brain. Although Max doesn't trust him completely, Brain sets out to protect Max in the best way he can as they discover who really betrayed S1W.

Alina Herrero contacts Eyes Only and asks him to help her find out the truth about her father's disappearance years ago. Max breaks in to the police department to steal information about her father, who also happens to be Logan's mentor. At the same time, Sketchy loses the mob's money and has to return the full amount in 36 hours. Max uses her super skills to win the money through poker.

Brin contacts Zack before she is captured. Max and Zach has no choice but to force Lydecker to tell her whereabouts. They teamed up and follow Brin to a military facility where Brin is to be sold to the highest bidder. Once there, Lydecker double crosses the two X-5s and decides to be in on the sale. Max and Zack manage to escape from captivity with Brin who is suffering from a condition that speeds up aging. She has no choice but to receive help from Lydecker. Max and Zack accept Brin's decision and leave her to be picked up by the man who made them.

Max must break her vow to avoid Logan after Joshua becomes a target of transgenic manhunt in the sewers. Ames White leaks news of the human-looking X-5's to the media.

Max regains her consciousness after her heart transplant, only to realize that she is back at Manticore and that Zack's heart is beating inside her. Madame X or Dr. Renfroe brings her to what is remain of Zack, his various organs taken to save other X5s. Now that the DNA lab has been torched, Manticore has decided to designate a 'breeding partner' to every X5's. Max's turns out to be Alec, a clone of Ben, who has no problem with her refusal to 'mate' with him. With the help of Joshua, a half dog- half man experiment, she escapes from Manticore for the second time. Outside in Seattle, Logan, after 3 months, still believes that Max is alive. He decides to reveal the existence of Manticore through Eyes Only. Dr. Renfro must destroy all evidence of the facility and burns the place, with people still trapped inside. Max cannot bear to see them die and releases everyone. Logan is reunited with her, only to find out that she is deadly to him if they touch because Manticore has given her a special virus targeted at him. Luckily, Max is able to retrieve the anti-body from Dr. Renfroe, who ends up taking a bullet for Max because, in her words, Max is special. Dying, she tells Max to find Sandeman.

Logan and Max track Aimes' kidnapped son to a small town where the breeding cult is readying Manticore's youngest creations for a mysterious ceremony.

Logan Cale's legs are failing him and he secretly contacts an ex-Manticore scientist in an attempt to get back on his feet. He tries to avoid the suspicious Max from knowing. Max's curiosity leads her to follow Logan on one of his trips when she is attacked by Jace, one of her X5's siblings who refused to escape.

Max needs her pills to keep her seizures at bay but her friends believe that she's an addict. Max is feeling the serious side effects from the alterations to her biochemistry. After her friends flush her pills she tries to steal some from the local hospital but get's caught and lands up in jail.

Tensions escalate into a showdown between White, the breeding cult and a group of Transgenics, and the employees of Jam Pony get caught in the middle.

A transgenic with the ability to control people messes with Max's mind to keep her from coercing a meek mob bookie into selling out his boss to Eyes Only. But once the mutant sets her sights on Alec, the stakes are raised, leading him back into the boxing ring to make some money for some not-so-good fellas.

A mermaid is caught by fishermen and is immediately sold to a night club in Seattle. Max and Alec are intent on returning her to the sea before White and his crew get their hands on her.

Max is rushed to the emergency room after she gets shot trying to protect a little boy. While there, blood and DNA tests expose the virus inside of her. The CDC is contacted, Ames White catches wind of it, and it's a race against the clock for Logan to help Max escape.

Max and Logan are out for a holiday. Unbeknownst to Max, Logan is also planning to investigate an old crime. Once there, Max befriends a small boy with a secret. Stirring his past brings troubles from the town's gangster to Logan and Max. Meanwhile, a powerful seizure takes over Max.

In a post apocalyptic world genetically enhanced female (transgenic) Max Gueverra tries to stay ahead of the law while looking for links to her past. Max does a job for Logan (the last good man on Earth; and cyber journalist Eyes Only) while trying to keep a handle on her revved up hormones, thanks to Manticore. Logan manages to turn up some information on a friend from Max's past.

After nearly infecting Logan, Max decides to end their affair for good; Alec's haunted by the sins of his Manticore twin; also Aimes White triggers a witch hunt by leaking information about the Manticore transgenics.