A running gag in the film is that when the refrigerator is kept open too long, the song "Macarena" by Los Del Rio plays. Director Vasilis Katsoupis has said in an interview that he wanted to find the most annoying song he could think of for the gag, and had tried to get "We Built This City" by Starship but could not secure the rights.
Enfermé (2023) was shot in chronological order, which director Vasilis Katsoupis likened to filming a documentary.
Principal photography wrapped on 1 June 2021. The film had its world premiere at the 2023 Berlin International Film Festival on 20 February 2023.
Principal photography wrapped up after seven weeks of filming at Cologne's MMC TV & Film Studios.