The show was announced for a pick-up of a second season on October 29, 2020. The announcement came with the news that the show would be moving to Auckland New Zealand, Lucy Lawless' hometown, being set there as well as filming there, likely due to the covid-19 virus. Ebony Vagulans, who plays Madison will also be returning.
According to a Parade.com interview, August 5, 2019, - Ebony Vagulans was the last person to audition for Alexa's sidekick, Madison. Lucy Lawless said she knew she was the one when she met her, stating that that Ebony came in with a lot of energy, intelligence, talent, and that she felt comfortable with her.
Lucy Lawless who stars in the series also serves as executive producer. It's only her second producing credit, The first one was in 2000.
Since the second season was moved to New Zealand, Todd River, who played Alexa's cat, Captain Thunderbolt, could not go, therefore a new cat was cast for the second season. Lucy Lawless tweeted that her cat, Chowder, was originally going to play her cat in the second season. However, it seems her cat ended up not playing him and another cat was cast, Zeppelin. Nonetheless, the character of Alexis' new cat was given the name of Lucy's cat, Chowder.
It was announced on February 10, 2022, in Variety, Collider, Deadline, and other entertainment news sites, that the series was renewed for a 3rd season. It is again expected to have 10 episodes. The My Life Is Murder (2019) official Facebook page has confirmed in replies that it will be filmed in New Zealand again. Ebony Vagulans, Rawiri Jobe, and Joseph Naufahu returning to their roles along with Lucy Lawless. At the time of the announcement, no air date was set yet.