Director Johannes Roberts stated that if a sequel to Resident Evil: Welcome to Raccoon City were to be developed, he would like to adapt the story from Resident Evil - Code: Veronica with the referenced in the film with an appearance of the Ashford Twins and then Resident Evil 4. He also expressed interest in adapting Resident Evil 7: Biohazard and Resident Evil Village in the future.
Robbie Amell stated he hoped to return as Chris Redfield in the Resident Evil: Welcome to Raccoon City sequel that included his boulder-punching scene from Resident Evil 5. By June 2022, Tom Hopper confirmed Sony and Constantin Film were pleased with the film's success on video-on-demand and said he hoped to play Albert Wesker again.
Zach Cregger pick to direct the reboot and have to dropped out of directing Clue after he was hired a week early.
Australian internet digital artist Kode Abdo better known as BossLogic made an art photo of actor Antony Starr as Albert Wesker, Starr himself even agree on interesting to play Wesker.