This is the first Looney Tunes full length theatrical film to not have June Foray voicing Granny, following her death four years prior.
After the original idea for "Space Jam 2" was canceled, there was an idea for a spy film titled, "Spy Jam" starring Chinese actor Jackie Chan. But he left the project and it evolved into Looney Tunes: De nuevo en acción (2003).
Bob Bergen is the only voice actor to return from Space Jam: El juego del siglo (1996), and as it happens, for the same role (as Tweety).
The film was released in July 2021, which marked the 25th anniversary of the original Space Jam: El juego del siglo (1996).
Kath Soucie had been set to reprise her role as Lola Bunny, and had all of her dialogue recorded. But for unknown reasons, she was replaced by Zendaya during late post-production.