Every sound made by Migi is actually a noise from a female Japanese beat-boxer named Rinka Ange.
The names of the first 21 episodes of the show are references to literary works:
- 1.01 The Metamorphosis, Franz Kafka
- 1.02 The Devil in the Flesh, Raymond Radiguet
- 1.03 Symposium, Plato
- 1.04 Tangled Hair, Akiko Yosano
- 1.05 The Stranger, Albert Camus
- 1.06 The Sun Also Rises, Ernest Hemingway
- 1.07 A Dark Night's Passing, Shiga Naoya
- 1.08 Freezing Point, Ayako Miura
- 1.09 Beyond Good and Evil, Friedrich Nietzsche
- 1.10 What Mad Universe, Fredric Brown
- 1.11 The Blue Bird, Maurice Maeterlinck
- 1.12 Heart, Natsume Souseki
- 1.13 Hello Sadness, Françoise Sagan
- 1.14 The Selfish Gene, Richard Dawkins
- 1.15 Something Wicked This Way Comes, Ray Bradbury
- 1.16 Happy Family, Lu Xun
- 1.17 The Adventure of the Dying Detective, Arthur Conan Doyle
- 1.18 More Than Human, Theodore Sturgeon
- 1.19 In Cold Blood, Truman Capote
- 1.20 Crime and Punishment, Fyodor Dostoyevsky
- 1.21 Sex and Spirit, Clifford Bishop.
This series follows a manga which was made in the 80s.
In the original Manga, Shinichi didn't wear glasses
Hayao Miyazaki and Toshio Suzuki were initially interested in adapting the Parsyte manga. However at the time they wanted to adapt the story, the rights were still held by New Line Cinema. New Line was attempting to adapt with Don Murphy producing, Takashi Shimizu directing and Matt Manfredi and Phil Hey scripting.