First time that the character Texas Ranger Earl McGraw (Don Johnson) has been portrayed by anyone else than Michael Parks. Parks previously portrayed McGraw in Del crepúsculo al amanecer (1996), Kill Bill. La venganza (volumen 1) (2003) and Grindhouse (2007).
Robert Patrick, who plays Jacob Fuller in the series was also in Del crepúsculo al amanecer 2: Texas sangriento (1999) and is one of three actors from the films to appear in the series. The other two are Danny Trejo and Tom Savini. With Danny Trejo being the only one who was in every From Dusk till Dawn production.
Wilmer Valderrama was so enthusiastic about working with Robert Rodriguez that he signed on without knowing which role he'd be playing.
Creator Robert Rodriguez had been waiting for a chance to work with Demi Lovato since she auditioned for his 2003 movie Mini espías 3D: Se Acabó El Juego (2003), so in the show's second season a character was written specifically for her and Rodriguez made sure it was an episode he directed. He was so impressed by her performance that he went on to direct the music video for Lovato's hit single "Confident".
Eiza Gonzalez said she had to do two things when she was cast: dye her blonde hair black; and gain considerable weight, as she had just finished a soap opera in which she played a bulimic girl, so she was really thin, She asked Robert Rodriguez: "Okay, so you want me to go to the gym and gain muscle," and he said, "No I want you to look timeless, like no one can tell what moment in life you're going through. I don't want you to look like a 2014 woman who's super ripped. I need real curves."