This movie features a total of six talking Pokémon, more than any previous movie. In the process, this number surpasses the record of five from Pokémon: Kyurem contra el Espadachín Místico (2012).
This is the fifth consecutive movie in which Ash and his friends do not meet Team Rocket. However, they are more prominently featured, attempting to capture Mewtwo and Genesect, as opposed to their brief, non-speaking cameos in the previous movie.
This is the first movie since Pokémon Ranger y el Templo del Mar (2006) to not feature Shôko Nakagawa as part of its cast. Instead, she appears in the accompanying Pikachu short, "Eevee & Friends."
This is the only Best Wishes series movie to feature Pokémon from generations prior to Generation V other than Meowth and Ash's Pikachu.
This movie has the shortest time between its Japanese and English releases, at three months.