The movie was mostly filmed in the unincorporated community of Eliasville, Texas.
Tipper Sommore and Connie Lingus played by Jenna Sky and Chaselyn Wade respectively, reprise their roles from Ticked-Off Trannies with Knives (2010), with Tipper explaining away her stab wound in the previous film as well as a fourth wall break when Tipper remarks "Deja Vu" when she sees Krystal Summers running up to their car in a panic as she also did in Ticked Off Trannies.
This film is dedicated to in memory of Erica Andrews who passed away in 2013. Andrews starred alongside most of the cast members of this film in Israel Luna's previous film, Ticked Off Trannies With Knives.