No CGI was used for the full body paint on Rob Riggle to blend in with the hotel hallway. It took six hours to paint him and blend in accurately with the vending machine.
The Farrelly Brothers couldn't get in touch with Brady Bluhm to reprise his role as Billy. They eventually found him through Facebook and were able to get him for the sequel. Due to regulations, Bluhm had to audition for the Farrellys.
Jim Carrey nearly dropped out of the sequel because he felt that the project's original producers, Warner Bros., weren't enthusiastic about the film. Carrey eventually decided to rejoin the project, although Warner Bros. dropped the project, which was then taken up by Red Granite Pictures and Universal Studios.
This marks the first film since Ace Ventura: Un loco en África (1995) where Jim Carrey reprises his character from a previous film. He wouldn't do it again until Sonic the Hedgehog 2 (2022).
Many of the KEN conference attendees are played by writers of the television series, Padre de familia (1999).