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Side Effects is a psychological thriller centered around the pharmaceutical industry. I won't say much more for fear of spoiling anything, but let's just say an experimental drug prescription goes... haywire. ;)

Steven Soderbergh crafts his suspense from the very first frame with a perfect start for the film. The plot then pulls us in and keeps us guessing as the mystery slowly unfolds. The cast meshes wonderfully. Jude Law delivers a strong lead as the frustrated psychiatrist and Rooney Mara is mysterious and unpredictable. My only complaint is the performances were not as dramatic as they could have been. Mara was excellent at portraying her character's cold and lifeless depression, but I have seen what she is really capable of (Fincher's "The Girl with the Dragon Tattoo"), and she could have definitely reached those heights with this type of character. Nonetheless, a fine set of performances all around, but they take a back seat to the intoxicating narrative.

So is Side Effects Soderbergh's last hurrah? I certainly hope not, as it's probably my favorite film of his. I do wish Soderbergh got more range out of Mara, but the result is a satisfying and expertly-woven psychological drama packed with twists and turns.

The poster of Side Effects features four famous faces on it: clockwise, you see Jude Law, Catherine Zeta-Jones, Rooney Mara, and Channing Tatum. There is a suggestion of a complex relationship between their characters - and of somewhat equal parts in the story. Both of those assumptions are proven false. Dr Jonathan Banks (played by Law) is gradually revealed as the protagonist of Side Effects, while his patient Emily Taylor (Mara) has a supporting, if most remarkable, role. Zeta-Jones plays the snake in the grass and spends most of the film out of sight, while Channing Tatum is briefly introduced as a handsome piece of furniture.

Side Effects has most in common with a Hitchcock thriller: Dr Banks faces a false accusation and must clear his name, with no support from his colleagues or from authorities. Characters are duplicitous and untrustworthy, and the question is not who is lying (everyone, everyone is lying), but how and why. Someone dies.

Rooney Mara delivers a great performance as a mentally unstable socialite - I whole-heartedly agree with Peter Bradshaw (The Guardian) praising her 'ability to be scared and scary at the same time'. As Mara's part is that of an unreliable narrator, it soon proves difficult to empathise with her character fully; instead, you spend a good while doubting her, yourself, and whether you are experiencing a déjà vu and whether you are experiencing a déjà vu.

There is no doubt that Side Effects is clever, yet, for me, the picture lacks in three important respects. The big questions about the use of mood-altering medication, experimental and otherwise, are raised, but then dropped as soon as the focus of the plot development shifts elsewhere. Two, the perilous and exciting romance - the supposed undercurrent of the narrative - feels shoehorned and staged. Finally, the ending brings us nearly full circle, and you are left wondering if the whole experience has had any effect on the protagonist.

Given that my original goal, when picking the film, was to see more praiseworthy acting by Zeta-Jones, I should find Side Effects satisfying. Unfortunately, as intelligent, ambitious, and well-acted as the film is, it lacks narrative cohesion and unity of tone, with the finale appearing as if a bow on a box.

Steven Soderbergh is a chameleon of a director and one of the few who has the ability to move from critically acclaimed Hollywood blockbusters, like Ocean's Eleven, to dramatic art films like The Limey. He is also one of the hardest working filmmakers today, taking on such roles as producer, writer, director, cinematographer and editor. As a director, he has been able to pump out two feature length films in a single year and he has done this more than just once. However, over the last decade his films have become weaker as it seems as though not enough time has been invested into exploring the emotional depths of the stories he is bringing to life. Therefore they lack the ability to conjure genuine emotion from their audience. It almost seems as if he does not care about whether or not audiences are moved or entertained, but rather is just doing his job, moving from one project to the next.

At the beginning of the year it was announced that Soderbergh was retiring as a director and that SIDE EFFECTS would be his last theatrical film release. In an interview with New York Magazine, he stated: "The worst development in filmmaking—particularly in the last five years—is how badly directors are treated. It's become absolutely horrible the way the people with the money decide they can fart in the kitchen, to put it bluntly."

Rooney Mara plays Emily, a woman who seems to be suffering from some sort of mental disorder after her husband, Martin, played by Channing Tatum, returns home from prison. After a failed suicide attempt Emily is introduced to Dr. Jonathan Banks, played by Jude Law, a psychiatrist who tries to help her by prescribing her an anti-depressant. As Emily's symptoms worsen, her psychiatrist and her try to find an anti-depressant that works for her. After many failed attempts Dr. Banks takes the advice of Emily's previous doctor, played by Catherine Zeta-Jones, and prescribes her a new experimental medication called Ablixa. The side effects attempt to destroy both of their lives.

Side Effects is shot and paced like a serious, well-crafted art film studying the truth behind depression which slowly builds into one hell of a tense thriller. What hold the film back is the ending. By the end this serious, well-crafted art film has succumb to a Hollywood twist gimmick popcorn flick better suited for the late 90's. I couldn't help thinking that someone had farted in the kitchen. I do not know if Soderbergh was just following the screenplay or if he was told to give it a happy ending that over-explains everything, leaving no sense of mystery and easily spotted plot-holes.

Of course, even with the out-of-place, poorly written surprise conclusion, Side Effects is still better than the majority of thrillers being produced today. And though it disappoints, the ride up until that point was mesmerizing and thought-provoking.

I saw a couple of interviews with the cast before this film came out and they talked about the fact that this film had a lot of twists and turns in it; and they weren't kidding. However, that being said I went in with a certain mindset and it took me a little time to figure it out, but I eventually did. Either the film was moving real slow for me or I have become accustom to seeing more action. This film is purely psychological in nature, so if you are looking for some action, there isn't any. It also got me to thinking how much power court appointed psychologists have and how they have the power to manipulate the system. On the other hand, it also made me realize that mental patients have absolutely no control over their lives (which may be a good thing). Dr. Jonathan Banks (Jude Law) is the psychologist on the case of a severely depressed patient. His world is quickly turned upside down by having to deal with anxiety, depression, pharmaceuticals and medical ethics. Emily Taylor (Rooney Mara) is the severely depressed woman who is desperately trying to find the right drug to cure her affliction. Dr. Victoria Siebert (Catherine Zeta-Jones) is a former attending psychologist of Emily who is consulted by Dr. Banks to try and uncover some of the dilemmas of her past. Martin Taylor (Channing Tatum) is Emily's husband and is shouldered with the responsibility of trying to care his wife as she tries medication after medication in addition to trying to keep the marriage together. Dierdre Banks (Vinessa Shaw) is Jonathan's wife and she becomes a victim and unwilling participant in the unfolding circumstances that is affecting her life. I think that the entire cast did an excellent job, but as I said before it was a tad slow for me in the beginning. This film definitely keeps you on the edge of your seat and you really do not know who is playing whom. It was difficult to know who to root for until all is revealed at the end. I thought that the story was a good one and it definitely takes you on a roller-coaster ride. I am not sure that anyone could ever reach the level of a Hitchcock film, but this one comes pretty close. Steven Soderbergh did an excellent job embracing this genre of film. I give this film a green light.

Steven Soderbergh has decided to end his career what can only be described as a pharmaceutical, psychosexual thriller that deals with several morally ambiguous characters all revolving around one horrible incident. Out of fear of giving away the intelligent, twist-filled plot written by Scot Z. Burns, that's really all I can say, although I can tell you that Soderbergh directs the film with extreme confidence, and it shows. He was able to convey a sort of quiet chaos with his frequent close-ups, and, by shifting in-and-out of focus throughout the screen, he was able to draw attention to the many small, yet important details.

The real strength of this film, though, is not necessarily the story itself, but how it is presented. To be honest, the story is almost too smart to the point of absurdity, but it never comes off as such. By releasing only one small piece of information at a time, we are kept waiting through interviews, court hearings, false trails, and many psychiatrist visits until, finally, everything comes together into one neat conclusion. The entire film is very subdued, but if you pay attention, you will be rewarded in the end.

Of course, the story would not have turned out so well without the multiple impressive performances that carry it all the way through. Rooney Mara is once again stunning as Emily Taylor, a woman who starts taking prescription antidepressants to cope with her husband's release from prison. Without giving much away, Emily is far more complex than she first appears, and Mara plays this perfectly by retaining a dark mysteriousness about her. She truly steals every scene she's in, and displays such a range of emotions that, at times, it's difficult to tell what her character is truly thinking. This is unfortunate for Channing Tatum, who does a fine job as her loving and sympathetic husband trying to make everything right after being released for insider trading, but who doesn't have close to enough material to compete with Mara.

Jude Law, on the other hand, is arguably the most central figure as Dr. Jonathan Banks, Emily's psychiatrist who is thrown into a scandal when his patient is involved in a tragic accident after taking an antidepressant he prescribed for her. He slowly mentally unravels as his decisions come back to haunt him, and eventually has to cross several moral boundaries in order to get his life back on track. Law shows this frustration with expert skill, and gives one of the best performances of his recent career. The same can be said for Catherine Zeta- Jones, who—as Emily's former psychiatrist Dr. Victoria Siebert—gives possibly the most complex performance, and does it brilliantly despite her lack of screen time.

To give away any more would be to say too much, as the film is so perfectly structured, it is difficult to discuss without giving away the whole thing. All I can add is, it is not so simple and straightforward as it may appear. It is a complex of characters, their motives, and the consequences of their actions, and, despite taking a while to get started, it is truly a spectacular, thrilling, and intricate journey that should not be missed.