The father of Captain Jack Sparrow was played by a Rolling Stone (Keith Richards), and in this movie, the uncle of Captain Jack Sparrow was played by a Beatle (Sir Paul McCartney).
This movie was being produced as Johnny Depp was going through a bitter divorce. He was chronically late to the set, to the point where it ate into the schedule as the set often came to a halt for several hours at a time. It got to the point where a production assistant was hired just to wait outside Depp's house and announce that he was awake when they saw the lights inside come on.
Although this movie was initially claimed to be the last one in the franchise, a sixth installment was announced after its release.
(At around six minutes) Henry (Lewis McGowan) recognizes a ship as Bonnet's ship called "Royal James". Stede Bonnet was a real-life pirate who worked closely with Edward Teach, a.k.a. Blackbeard. Bonnet was active from December 1717 to December 1718 before he was hanged in Charles Town for piracy.
For the first time in the franchise since Piratas del Caribe: La maldición de la Perla Negra (2003) (which he co-wrote with Klaus Badelt), Hans Zimmer is not composing the music for this movie. Instead, one of his protégés, Geoff Zanelli, who worked on all previous four installments in the franchise, is the main composer for this movie.