Championship motorcycle road racer Jeremy McWilliams was cast as the motorcyclist to handle the treacherous driving conditions of the Scottish Highlands.
Jonathan Glazer did not want to use make-up for the man with neurofibromatosis. Adam Pearson was cast after the production team contacted Changing Faces, a charity supporting people with facial disfigurement. His ideas about how Scarlett Johansson's character could seduce his character were added to the script.
A paparazzi still of Scarlett Johansson, in character, falling down became a wildly popular Internet meme in which users would photoshop Johansson into various situations. As the scene was shot with hidden cameras, it was not until the movie's release that it was revealed the fall was intentional.
Scarlett Johansson talked about her deciding to go nude for the film during a press conference. "I think in some ways you have to look at the nudity and sort of assume that it's going to be a screenshot for someone, and you kind of have to weigh the value of the risk that you're taking. You know, 'Is this gratuitous? Is this a vanity project? Is this an important part of this character's journey to self-discovery? What's the gain?" She ultimately decided it was right for the character and worth the risk. She then added, "I'm not a provocative person. It's not like I live to be photographed in the buff or anything like that." And not being provocative led to some apprehension when being asked to strip totally naked. "It really made me aware of when I was doing it, all the kinds of judgments and all of these things we place on ourselves. How self-conscious you can be about the way you look, your own vanity. It was really challenging but it was interesting like, 'I really am self-conscious about this or I'm holding on to this idea I should look like that.' We all have it. I guess as a woman, we have it more, I don't know."
Adam Pearson and Scarlett Johansson had a competition to see who could tell the most inappropriate joke. Pearson won but says that Johansson put up an excellent fight.