Liev Schreiber's second project based on Tom Clancy's work (Clancy came up with the idea for the Splinter Cell video games), having previously played John Clark in La suma de todos los miedos (2002).
In August 2024, Michael Ironside, who had previously voiced the character Sam Fisher in the video games, stated that he was too old to portray the character for television and that Liev Schreiber had taken over the role.