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80/100. This was so much more interesting than I was expecting. It tackles several issues and does so with finesse and without the over the top melodrama movies of this type so often have. It's touching, thought provoking and it is certainly not predictable. Nick Cassavettes deserves a lot of credit for creating a film that faces the issues without getting too maudlin and does so with sensitivity and objectiveness. The performances are good from everyone. The casting of Cameron Diaz isn't perhaps the best, but I admire the effort she put into the role. She did very well. The character development is outstanding, you get to know each character and you understand each of their perspectives. Joan Cusack is particularly affecting in an offbeat role for her. Good score, the subtle cinematography is effective.

Nick Cassavetes is almost like a walking advertisement for Kleenex at this point. After such shameless melodramtic weepers like "John Q" and "The Notebook", I wasn't so keen on seeing "My Sisters Keeper", based on the book by Jodi Picoult. Yet, every once in a while, a chick flick comes along that touches the chick in every man.

Cameron Diaz plays Sara Fitgerald, who along with her husband Brian (Jason Patric), makes the decision of genetically engineering a child who will be a direct match to their leukemia-stricken 2-year-old daughter Kate. Abigail Breslin plays the engineered child at age 11. Her name is Anna, who since the age of 5, has had blood taken from her and been put thru medical procedures to help keep Kate alive. Anna loves Kate, played as a teenager by Sofia Vassileva, but when her parents want to give Kate one of Anna's kidneys, Anna finally says enough. Sure that no one is looking out for her interests, Anna hires a lawyer (Alec Baldwin) and sues for the right to her own body. Sara, a woman who has made caring for Kate her full-time job, is upset while Brian understands. Meanwhile, Kate feels guilty that her disease is tearing the family apart.

Cassavetes and co-screenwriter Nicholas Leven are dealing with a straight-up tear-jerker here but it's astonishingly free of heavyhandedness and it cuts deep with probing questions and real emotion. These are characters with feelings and concerns, torn between such complicated issues as saving a daughter by experimenting with another, sacrificing your own body even though you know it will diminish quality of life, and dealing with how a disease can burden a family. The movie uses flashbacks (such as Kate being diagnosed as a young child, her parents being given the choice of invitro, and a very young Anna disturbingly forced into operations) and forwards (Kate lying in a hospital bed, looking at a scrapbook of her family) that add dimension. As do the switching of narrators, each character getting a chance to offer their points of view and feelings about how the diagnosis, and everything after it, has effected them.

Unfortunately it's also going in a lot of different directions, and add in a dyslexic and lost-in-the-shuffle brother (Evan Ellingson), and it's sometimes hard for Cassavete's to keep track of all of them. The second act, in particular, has very little to do with the Sara-Anna conflict and the more light-hearted scenes, such as the family frolicking happily on a beach together, seem odd because you feel like there is some contentiousness between Sara and Anna that really doesn't come out til the ending courtroom scene.

However these are small problems rendered almost excusable by powerful performances. Abigail Breslin has surpassed Dakota Fanning in all-out maturity, juggling her characters fears for her own well being with the remorse of not being strong enough for her sister. And Diaz is strong-willed but obsessive, perfect as a one-track minded mother so intent on trying to keep one daughter alive that she's not even thinking about anything else. Jason Patric is the open and understanding father and Alec Baldwin is good comic relief, playing a lawyer so cocky, he sued God. And Sofia Vassileva is nothing short of powerhouse, her heartbreaking performance rising above all the cancer make-up and bloody vomitting and nosebleeds to find Kate's burdensome guilt and brave soul. And only stone-hearts won't share in her joy as she gets dressed up and goes to prom with another terminally ill boy (Thomas Dekker).

I'm not saying this movie isn't a cheap excuse to make you cry, but as far as cheap excuses go, this one is richly made. "My Sister's Keeper" is as surprising and heartfelt a piece of work as I've seen all year long, and the acting is about as good as it comes. With this and his previous, "Alpha Dog", Cassavete's signals himself as a real filmmaker as he rarely ever hits a false note. In a year filled with movies that I've seen fail at finding the humanity in their stories, this one is a keeper.

I'm currently in the middle of a battle in witch my aunt just finished fighting and beating cancer for the third time but I'm not here to discuss that... I'm here to explain how this movie is compelling, realistic, and above all moving.

This movie shows the struggles and sacrifices many families come across during battles involving not only cancer but also all diseases. It shows the drama, love, fighting, and encouragement that all people face in battles but it also shows that most of the time it isn't happy or encouraging to go on fighting but instead a painful road to ride on.

This movie helped me rekindle a little faith I lost over the last few years, and to prove that this movie is for everyone, I'm an 18 year old male Canadian Solder so if anyone says guys can't watch this movie their wrong because this movie speaks to everyone.

Trust me... This movie is a story of Heroes, and I'll never forget it.

In Los Angeles, the eleven year old Anna Fitzgerald (Abigail Breslin) seeks the successful lawyer Campbell Alexander (Alec Baldwin) trying to hire him to earn medical emancipation from her mother Sara (Cameron Diaz) that wants Anna to donate her kidney to her sister. She tells the lawyer the story of her family after the discovery that her older sister Kate (Sofia Vassilieva) has had leukemia; how she was conceived by in vitro fertilization to become a donor; and the medical procedures she has been submitted since she was five years old to donate to her sister. Campbell accepts to work pro bono and the obsessed Sara decides to go to court to force Anna to help her sister.

"My Sister's Keeper" has a potential story with a promising beginning. However, the screenplay entwines flashback of situations of Kate's cancer sometimes in a confused way and has a melodramatic conclusion that could be shorter. The greatest problem is the shallow and unrealistic Hollywoodian approach, reducing the strength of the powerful drama, and I believe that this theme would be better explored by an independent director in a more realistic environment. The teenager Sofia Vassilieva has an awesome performance and Cameron Diaz is also great in the role of a mother that becomes obsessed to save her daughter and forgets her family. My vote is seven.

Title (Brazil): "Uma Prova de Amor" ("A Proof of Love")

Although the film differs from the book, it is still amazing. The acting was believable and you could really see the heartbreak of the family. But, there were also some funny moments, making the movie slightly uplifting. I am a huge fan of the book, and if i had been expecting to see on the screen exactly what is in the book i would have been disappointed. However, the film has earnt the 10 stars respectively and should, in my opinion, receive an Oscar. I can tell already that the actress who plays Kate will go far in the film industry and i feel that Cameron Diaz has done herself proud, discarding her comedy label. Overall, a brilliant film with a strong message.

(Synopsis) Sara (Cameron Diaz) and Brian Fitzgerald (Jason Patric) have just been informed that their young daughter Kate (Sofia Vassilieva) has leukemia, and that she only has a few years to live. The doctor suggests to the parents that they try an unorthodox medical procedure of producing another child in a test-tube that would be a perfect match as a donor for Kate. Sara will try anything to save Kate, and they have a new baby Anna (Abigail Breslin) to be used as a donor for Kate. The first thing they use is blood from the umbilical cord for Kate. As years go on, the doctors must take bone marrow from Anna to give to Kate. At age 11, the next thing Anna must give to her sister is a kidney. Anna has had enough of all of these medical procedures, and she decides to sue her parents for medical emancipation and the right to decide how her body will be used. The whole family is being torn apart by Anna's decision because everyone knows what will happen to Kate if she doesn't get a new kidney.

(My Comment) Everyone knows from the movie trailer that the story is about a young girl who has cancer. You would think that it would be a depressing movie, but you would be wrong. It is a story of some of the choices we make in life. Having a test-tube baby as body parts for another child was a choice made by the parents. Anna wanting to stop giving her body to her sister was a choice. As with all choices, there are consequences. Kate will die without a new kidney. There are many very hard choices in life and in death that we must make, and this is a good movie to show you the way. Diaz as the pragmatic lawyer who was fighting to the very end for her daughter lost focus on life, and the rest of her family. I believe that this is Diaz's best part and performance as an actress. Sofia Vassilieva played Kate, who was in pain for most of her life. Sofia played Kate so well that you could see the helplessness in her eyes as she fights for her life. Anna was also part of this pain, and Abigail Breslin played this part as a professional. Actually, the whole cast was outstanding throughout the film. I loved the collaged scrapbook with voice-over and flashbacks that Kate made to give to her mother. This is a good movie to see with your loved ones. (New Line Cinema, Run Time 1:49, Rated PG-13) (10/10)

One of the most interesting movie going experiences came when toward the end of this film, the noise of someone blowing their nose filled the theater. A soft giggle then filled the theater. I hate to say that this is one of "those movies," where you know there's a chance that you might end up in tears by the end, but I'm afraid it's true. The struggle between life and death, not only for middle child Kate, but also for the whole family, is heartwarming. Cameron Diaz, takes a serious turn, somehow she seems very comfortable in this role. And Sofia Vassilieva shows both sides of cancer. The heartache and the pain, but also the beauty in how tragedy can bring families together.

The movie was actually very well-put together, but they left out several important things that were in the novel, including the existence of a child advocate, the way the court found out about the reason for her suit, and the fact that in the novel, Anna lived at the fire station for most of the trial because her mother was the opposing council. Let's not forget the fact that they added characters --the aunt and the various other family members. They even changed the end of the story! The majority of the details remained the same, such as Campbell's condition, the name of his service dog, and most of the listed medical procedures Anna endured, but there are still depths of the story that are left out because of the narration style (they did well at the beginning, but they tried to keep it all from Anna's POV after that, and that doesn't work for this story...) This is actually one of the reasons I wasn't sure I wanted to watch the movie: Hollywood is prone to ruining good stories. The movie was wonderful, as long as you don't try to reconcile it too closely with the novel it's based on.

This movie is amazing, heart worming, sad, fantastic. I read the book, yes there is some changes done, but is all the movies turned into books just like the book? Are they really going to do every single thing? No. Yes the ending isn't the same as the book, but the ending was still sad. If you see this movie and don't cry, than you don't have a heart. The acting was fantastic. The best I have ever seen. I cried. Yes I'm a 16 year old teenage boy. I cried, even my dad, a 48 year old cried. It's girlie movie, But a damn good one at that. It's the must see of the year. Of course it did poorly at the box office cause they decide to bring a movie more directed to being sad out at the same time as transformers2 (which was stupid). But really you need to go see the movie. and bring something to dry your eyes!

"My Sister's Keeper," much-loved novelist Jodi Picoult's first book-into-movie, is about death and familial love. It looks death straight in the eye and comes up blank. As it should. The film's conclusion is that we don't know much about death or the afterlife, but we do know about love.

A very determined mother is impregnated with a daughter who is specifically designed by medical science to be compatible "spare parts" for her sick older daughter (leukemia). At eleven years old, the younger daughter sues for control over her own body. Sound like creepy sci-fi? It's not at all portrayed that way. As these technologies become commonplace (think: Sarah Jessica Parker and Matthew Broderick's twins, recently carried and birthed by a surrogate mother; Octomom; the widespread use of IVF; sperm and egg "donation"; frozen embryos; etc.), emotional, home-y narratives will accompany these decisions/choices/actions, and thus, these stories will become just "normal." As is well known, the Catholic Church sees the above-mentioned "solutions" as disrespectful of human dignity. Anything that treats human beings as objects, things, products, tools, "rights," possessions, etc., is not in keeping with that dignity. (Certain technologies to aid fertility ARE approved, as long as it's within the context of the nuptial act, aiding the natural process. Contrary to popular belief, the Church wants you to have sex, and is very back-to-nature, crunchy granola.) "My Sister's Keeper" is really a bio-ethical drama, but I've never heard anyone put it in that context which is kind of scary in itself. It's also a legal drama—what are the little girl's rights, if any? While watching the film, one is acutely aware that this is simply the state of the question/problem FOR NOW. Things are only going to get weirder.

The conclusion-twist, although altogether a probability, clever, generous and heroic, felt like a bit of a cop-out (like the miscarriage in "Citizen Ruth"). Why NOT follow the real question through to the end? Actually, we know such cases have already happened (families having a child for the therapeutic purpose of healing another child). What ARE the rights of these too-young-to-speak-for-themselves-de-facto donors? Should this ever be done? (Starting from babyhood, Anna has been through many painful procedures with side effects that compromise and jeopardize her health.) This film is quite well done (director Nick Cassavetes, "The Notebook"), and only treads the edge, but never falls into the chasm of sentimentality. This is not to say that you won't be sniffling.

In the courtroom, Anna's lawyer comes close to asking: "Where does our 'culture of absolute choice' end?" We pretend it ends when my rights crash into yours, but that happens early on in many cases, and I'm afraid we've learned to deny, justify or just force our way.

There are very few movies that I can't watch again and this is one of them. It's a great movie, but it is a rough one to watch. There is so many deep emotions going on within this movie, but the emotions that overwhelm you are of great sadness. Also, it's not easy to watch the suffering that she goes through in a lot of scenes with her afflicted disease. This is not an easy film to get through but it is an amazing story to see.

It won't be for everyone as it is a troubling film to see on all levels, but at the same time it gives the viewer a lot of perspective and awareness on living one's life to the fullest while we're fully healthy, and that's something to be very thankful for.

Outstanding performances all around, beautifully acted although I must say Jason Patric was a stand out performance for me. He's such a terrific actor, and I wish I saw more of him. Worth the watch if you can stomach it.

I loved the book. I have say the book had me in tears almost the entire way through. After seeing the movie I was seriously disappointed when they changed the ending. It ruined the whole book experience for me. By changing the end of the movie they ruined the whole integrity. The whole message behind the story was turned into just another movie about a dying girl.

I don't want to say what the end of the book was because if you haven't read it, I don't want to ruin that experience for you. The rest of the movie, besides the ending, did follow the book somewhat. What I miss is the whole perspective of Anna. It was only briefly given in the movie.

I would say this is a good movie, but if you're a huge fan of the book, I think you'll be disappointed.

I have to disagree with the bad reviews that this movie is getting. Unlike "Twilight" which left important and essential parts from the book, My sisters keeper included the most important and the most memorable from the book. I am a fan of Jodi Picoult, don't get me wrong, and I really didn't mind the ending. Sometimes endings need to be changed for the benefit of the movie, and I believe this time it was a good call. I am a huge fan of Jodi Picoult. I really loved the book, but I think the movie made was so much better. The acting displayed in this movie was exceptional, they replaced the characters I had created in my mind while reading the book. The emotion displayed really hit me hard, and I cried from the beginning until the end. There are worries that Alec Baldwin ruined the movie, in my opinion he did a great job. So stop being bitter, and go see it people!