The part of Nate Tanner was originally supposed to be James Dalton, Patrick Swayze's character from the first El duro (1989), but Swayze backed out due to creative differences, and the character was changed.
The ventilator was a real working ventilator. An artificial lung was placed off camera to make it work.
Was supposed to film in New Orleans, Louisiana, however, switched locations after Hurricane Katrina devastated the city.
The twins girls who are seen with Shane, the main character, on the front of the "Road House 2" DVD cover are implied to be supporting characters in the film. These woman are only seen as extras leaving the Black Pelican bar in the film's opening scene, and neither of them have any dialogue.
The twins you see at the beginning of the film are entering the Black Pelican not leaving it.