There are frequent insulting references to MTV in the guise of "POP" music channel. Usually in the form of a sign with the "POP" channel's logo (which is very similar to MTV's) being smashed apart.
XLR stands for "Extra Large Robot".
In the episode "Coop D'Etat", the main robots, Zanzoar and Gyven, are parodies of Optimus Prime and Megatron from The Transformers: The Movie (1986). They are also voiced by the same voice actors: Zanzoar is voiced by Peter Cullen, and Gyven is voiced by Frank Welker.
Magnanimous's giant robot in the episode "The Return" is modeled after Ash from Evil Dead and Elvis Presley from Bubba Hotep, both of which were played by Bruce Campbell, who voiced Magnanimous.
Jody Schaeffer and George Crstic used to write for MTV's Downtown, which is where they got the character Goat. This could explain the destruction of the MTV logo in each episode.