During season two, Terri MacGregor becomes a successful plus size model. In real life, the actress who plays Terri, Christina Schmidt, left the show to become a real life plus size model. She is represented by B&M Models in Toronto and has been featured in Italian Vogue, as well as ads for Torrid, MXM, and Nygard.
In the episode "Take My Breath Away" (2x10), Craig and Manny go on their first date. Later, while Craig is talking to Jimmy and Spinner, he says that Manny kept reminding him of his little sister, Angie. In fact, Cassie Steele (Manny) and Alex Steele (Angie) are sisters in real life.
Mr. Simpson is the only character to be a regular throughout every season of Degrassi, including Degrassi Junior High.
J.T.'s full name, "James Tiberius," is a reference to Captain James Tiberius Kirk from Viaje a las estrellas (1966).
Adam is the first scripted transgender teen character in television history, not including documentaries or one-time guest roles.