Meryl and Milly are searching for the Legendary "Vash the Stampede". They are rumored that it is a man that is twelve feet tall and has a green mohawk. A while later they meet a man befitting the description, but this man has already captured a man that he is convinced is Vash.
Meryl and Milly seek shelter in the mansion of Cliff Schezar, a wealthy man who has hired Vash as a bodyguard! Have the girls finally found the infamous gunslinger? Or is Cliff hiding something?
Vash is looking for a renowned gunsmith named Frank Marlon. He finds him - but the legendary craftsman is a drunken mess! Making things worse, a group of bandits has learned that there's no sheriff in town!
Vash finds himself in the middle of a hostage crisis when outlaws take the mayor's daughter - and Meryl and Milly - captive. He quickly discovers that these bad guys might not actually be the bad guys!
With an entire town after the bounty on his head, Vash must contend with the dangerously destructive Nebraska Brothers - while saving the very same villagers who are bent on bringing him in!
Vash is completely smitten with Elizabeth, a stunning beauty who has arrived in town to repair the local plant. Hopefully Vash isn't too distracted by her charms - because the enemy is very close indeed.
Injured but still staying true to his beliefs, Vash battles the gang with Meryl, Millie and Kaite's help. A song stirs old memories and emotions, giving a glimpse into Vash's past.
A bus trip is interrupted to pick up a priest with a giant cross, Nicholas D. Wolfwood. Large robots attack the bus as it leaves. A small child is left behind and Vash and the newcomer get out to fight the robots and save him.
Vash and Wolfwood enter a quick-draw competition in May City. If one of them wins, the prize money will go to a poor local family. Unfortunately, they're both in line of fire - the contest is rigged!
Vash is thrown in jail after being accused of killing a local shoemaker. Even if he gets out of his cell, there's going to be trouble - Monev the Gale is gunning for him after being hired by Legato!
An elderly couple asks Millie and Meryl to help them protect a piece of valuable property from their rivals. With hired killers nearby, and Vash nowhere to be found, Meryl and Millie might be in over their heads.
The Roderick gang's battle with Legato is violently interrupted by the fierce Gung-Ho Guns. Just as Vash begins to investigate the incident, he meets Dominique the Cyclops, a lethal beauty with an amazing power.
Vash faces off with two of the Gung-Ho Guns: E.G. Mine and Rai-Dei the Blade. When the action heats up, Vash the Stampede is forced to unleash a new and devastating attack.
Wolfwood meets Lina, a girl who's having trouble with a guy who claims to be Vash the Stampede. When she's abducted, Wolfwood must team up with an odd fellow name Erics to save her.
With reports of new Vash sightings, Meryl returns to the work of tracking him down. Meanwhile, Vash and Wolfwood make their way to a town where a family feud has escalated into a hostage situation.
Vash and Wolfwood are in danger on the Project Seeds ship. The Puppetmaster's goons - members of the Gung-Ho Guns - are on a killing spree and the entire ship could be destroyed.
Vash and the gang meet a group of orphans whose parents vanished after falling victim to a strange trance. Is it Legato's doing? Or is there a secret villain hidden among the children?
Wolfwood decides it's time for one last duel with Vash, but the gunslingers' face-off is interrupted. Vash takes off after Caine the Longshot, while Wolfwood faces Chapel the Evergreen.
After Vash faces Midvalley the Hornfreak, he squares off with Legato for a final showdown. Making matters worse, the townsfolk are stuck in the middle of the chaos!
Meryl and Millie are doing their best to get by as Vash recovers, but when the locals discover that the infamous gunslinger is nearby, they set out to make him pay for their recent pains - with his life.
In the series finale, Vash must face his past and finally confront his brother Knives. Will he be driven to break his only rule in facing him, or will he find a different path?
