Trivia

Hayden Christensen replaced Jared Leto who originally was considered to play the main character.

The tagline is a gross misrepresentation of statistics. The actual estimate of awareness during anesthesia is 1:14000 for high risk patients to as low as 1:42000.

Jessica Alba replaced Kate Bosworth after she dropped out to shoot Superman regresa (2006).

Helen Mirren and Sigourney Weaver were both considered at one point to play Lilith Beresford before Lena Olin was cast.

Not screened in advance for critics.