Eddie Vedder of Pearl Jam picked Todd McFarlane to do their music video for "Do the Evolution" after watching a Spawn episode on HBO in 1997.
The whip-crack sound effect of Spawn/Al Simmons' chains popping out from his robes is the same as the activation of the alien's heat vision in Depredador (1987).
As of 2000, the first season was HBO Home Video's top-selling original programming video of all time, with combined sales topping 1 million units.
Angela wears earrings with a design of Spawn on them.
Wanda Blake's new husband, and Al Simmons's former friend is named Terry Fitzgerald. One of the producers of the show is also named Terry Fitzgerald.