The actor who plays Banshee, Jeremy Ratchford, also voiced Banshee on the '90s X-Men cartoon.
The mansion used for the Xavier Institute is Hatley Castle, which was also used as Xavier's school in the films X-Men (2000), X-Men 2 (2003), X-Men III: La batalla final (2006), X-Men: Días del futuro pasado (2014), Deadpool (2016) and X-Men: Apocalipsis (2016). However, each of the feature films also used various other locations to portray parts of the school. Hatley Castle also served as the Luthor family mansion on the television series Smallville (2001) and as the Queen family mansion in early seasons of the television series Arrow (2012).
The characters of Buff and Refrax were created especially for the movie. Characters such as Chamber and Penance were left out because the SFX needed to portray them would have raised the budget too high.
Generation X was the first original product of Fox acquiring the X-Men's film and animation rights from Marvel.
Sandra Oh auditioned for the role of Emma Frost