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What we have here is a cute lovable dog taken as a pet into a house by a news reporter Lori (Ally Sheedy) after she rescues him from a genetic research facility, unaware that Joseph Mengele's brother Jarret (Lance Henriksen) has genetically altered the dog performing vivisection giving him enhanced strength, speed, and senses. The dog can climb trees, understand different languages, he enjoys being a peeping Tom when couples get intimate, ( but we dont get to see any nudity), the dog can copulate n produce multiple puppies n most of all it can camouflage itself. Watch out for the camouflage scene man. The film has some nasty kills but mostly offscreen n it lacked tension apart from the poor cat scene. The tag line ridiculed Cujo but they forgot that Cujo is filled with genuine tension n suspense.

I first saw this in the mid 90s on a vhs. Revisited it few days back.

I was highly disappointed to see that the dog who plays Max in this film is not credited anywhere on the IMDB page - and he was the best actor in the whole darn movie! The whole half-dog/half-human brain thing (at least I think that's what it was supposed to be) was pulled off incredibly well by this pooch. I mean, he had EXPRESSIONS! When he looked up at Ally Sheedy's boyfriend after he tried to slip him some spiked dog chow - that LOOK! GRRRR!!! It was great! That dog should get an Oscar! ;-)

"Man's Best Friend", about a genetically altered dog that kills any perceived threat, is pretty much what you'd expect. Ally Sheedy really chews the scenery as the reporter investigating cruelty to animals and inadvertently releasing the bloodthirsty pooch. But no matter, the movie still is pretty fun to watch, with the full understanding that it's basically a totally dumb flick. Lance Henriksen, playing the scientist who created the murderous hound, lets his face do the acting.

Like I said, it's mostly just a fun movie to watch. Definitely nothing special about it. Although I should admit that I'd never heard of a Tibetan mastiff until I read a description of the movie.

This mutated dog sci-fi/ horror / black comedy requires complete suspension of disbelief, and if you can live with that premise, you will find "Man's Best Friend" entertaining. Although Lance Henriksen receives second billing, his screen time is somewhat disappointing. The sci-fi element is never explored, giving way to "Cudjo"-like maulings and some moments of "dark comedy". There is a little too much cutesy stuff involving the genetically engineered dog, but overall other than the lack of Henriksen, this is a totally acceptable time waster. The dog is really the star, with the actors assuming a secondary role. - MERK

Lori Tanner (Ally Sheedy) a mediocre reporter who dreams of big-time. She gets her big break as she sneaks into a laboratory that is accused of having animal cruelty. She unwittingly releases poor pitiful Max, a lab experiment hound, in her pursuit for justice and a great story.

Max returns the favor by protecting her from a mugger. They soon bond and Lori is oblivious to Max's potential for good or evil.

The fun part of the movie is that we get to see Max's potential for good or evil. The situation makes us cheer for Max and overlook his few foibles. We also suspect and look forward to our local authorities (Robert Costanzo, and John Cassini) becoming dog chow.

It was a nice touch having the comic relief of dog catchers in this presentation.

It's not the best film or the worst or the best story or the worst but it is worth watching.