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Four medical students—Joe Hurley (William Baldwin), David Labraccio (Kevin Bacon), Randy Steckle (Oliver Platt), and Rachel Mannus (Julia Roberts)—help colleague Nelson (Kiefer Sutherland) conduct a dangerous experiment in which his heart is stopped and then resuscitated, the goal being to learn what happens after death. One by one, the rest of the students do the same until they begin to experience hallucinations brought on by their unleashed memories. When one of those hallucinations suddenly becomes physical and harms Nelson, the students realize they are in danger for things they have done in the past.

Flatliners is based on a screenplay written by Peter Filardi. The story was novelized in 1990 by Leonore Fleischer.

He was a crack cocaine user having a fit.

She was hemorrhaging vaginally. Nelson suspects that it was due to a botched street abortion.

The procedure, as described by Nelson, is this:(1) Anesthetize him with sodium pentothal and nitrous oxide. (2) Cool down his body temperature with a refrigerated blanket. (3) When body temp reaches 86°F, zap him with 200 joules to stop the heartbeat. (4) When the heart is 'dead', take off the nitrous mask. (5) When the electroencephalogram (EEG) flatlines, wait 30 seconds then begin warming the body. (6) When the body has reached 96°F, inject 1cc adrenalin and wait for one more minute. (7) Zap him again with the defibrillator in order to start his heart beating again.

Hoka Hey. It's a Sioux war cry.

Bretylium is real. It is an anti-arrhythmic drug used for ventricular tachycardia (rapid heart beat) and fibrillation (irregular heart beat). One of its side effects is hypotension (low blood pressure), so it's presumed that the reason Bretylium would "fry" Rachel is that, if it didn't result in giving her back a steady heartbeat, the side effect of lowering her blood pressure would guarantee her death.