This cartoon was a huge success when it first aired on American Broadcasting Company (ABC) and later became one of the first cartoons to air on the Fox Network's Fox Kids Network lineup. This led to Beetlejuice being seen Monday through Friday on Fox Broadcasting Company while still remaining on ABC's Saturday morning schedule, making it one of the few shows in American TV history to be aired concurrently on two different broadcast networks.
It is not known who played the announcer who says "Now here's Beetlejuice" during the title card and "Now back to Beetlejuice" after the commercial break; the actor is not credited in the end credits, and to this day the actor's identity remains a mystery.
The reoccurring character Prince Vince is the same one used for the title character Vincent (1982), an early Tim Burton short.
Beetlejuice's aliases on Peaceful Pines in the real world are Mr. Beetleman, Betty Juice, and Cousin BJ.
Jacques LaLean the bodybuilding skeleton and Ginger the tap-dancing spider are based on fitness guru Jack LaLanne and dancer/actress Ginger Rogers.