The elongated fingers on Mr. Pryde (when he first transforms), are a clear homage to John Barrymore's famous 1920 version of Hyde. Ironically, the makeup and prosthetics are noticeably better in this spoof than they were in the original, possibly because five years had passed, giving special effects makeup time to progress.
The original ending of the film is missing. In some prints, a few seconds have been cut off to provide an ending of sorts when the girl hits Pryde with a bottle, but the longer version shows Pryde recovering from the blow, pulling her towards him and looping her necklace around his neck, as the mob arrives outside the locked door.
In the British copy, the direction is erroneously attributed to Harry Sweet; According to Richard M. Roberts, "all original source material on DR PYCKLE AND MR PRYDE that I have seen indicates Percy Pembroke as director. I don't know where somebody got Harry Sweet as the Director (most likely wishful thinking on somebody's part as Sweet directed the two Stan Laurel/Joe Rock Comedies on either side of it, THE SLEUTH and HALF A MAN)"
This film was used by Jay Ward on Fractured Flickers as the basis for the "Minute Mysteries" skits in several shows. The Mr. Pryde character was christened as "The ace detective Sherman Oaks. (The joke being, Sherman Oaks is a Los Angeles suburb).