Bonnie Dennison played Jenny in the pilot, but the role was recast, and she was replaced by Ashley Tisdale.
Despite having a devoted fan base and good reviews, CBS officially declined in May 2020 to renew Carol's Second Act (2019) for a second season, reportedly because of inconsistent week-to-week ratings.
The series finale, R.I.P. Dr. Herman (2020), aired the night after the World Health Organization officially declared COVID-19 a pandemic. The following week, most non-essential workers around the world, especially in the United States, were ordered to stay home.
Writer Emily Halpern previously wrote for another medical series, Private Practice (2007). Neither of the head writers are doctors.
The show was taped in front of a live studio audience.