An accompanying music video was directed by Ruth Hogben and Andrea Gelardin.
Cover versions of the song were recorded by singer Kelsea Ballerini, Grateful Dead's Bob Weir and Phish's Trey Anastasio.
Billboard ranked "Million Reasons" at number 35 on their "100 Best Pop Songs of 2016" list.
"Million Reasons" reached the top 10 of the charts in Hungary, Slovakia, Switzerland, the United States, and Venezuela as well as the top 20 in Canada, Italy, and Scotland.
It lyrically delves on "heartbreak and hope" during a relationship, as well as Gaga's religious faith during the chorus, ultimately making it a song with a positive message.