For the Doctor Who property, the only actors to reprise their roles from the show are Peter Capaldi (Twelfth Doctor), Jenna Coleman (Clara Oswald), Michelle Gomez (Missy), John Leeson (K-9), John Barrowman (Captain Jack Harkness), Strax (Dan Starkey), Madam Vastra (Neve McIntosh) and Nicholas Briggs (The Daleks and Cybermen). The other Doctor Who actors' voices are archive audio.
Because of the game's unique crossover nature, certain characters will often have special dialogue whenever they are paired together. For instance, Doc Brown (voice of Christopher Lloyd) of Volver al futuro (1985) and The Doctor (voice of Peter Capaldi) will critique each other's mode of time travel transportation.
This is the first time that Chris Pratt plays two different characters from two different franchises in one story. His roles are Emmet from La gran aventura LEGO (2014) and Owen Grady from Mundo Jurásico (2015). When paired together, they might have an interesting conversation.
Tom Cruise is well known for not allowing his likeness to used in merchandise such as toys or video games. He made an exception however for this game, the Ethan Hunt Lego figure, and personally approved the use of the character's archive audio.
While the developer was able to get the license to "The Simpsons" characters in the game, they were not able to afford to bring in the original actors to reprise their roles. Therefore, the dialogue of Homer and Krusty are pulled from clips of actor Dan Castellaneta from the series, while Bart Simpson makes no sound at all. The Simpsons Level Pack level is based on the episode The Mysterious Voyage of Our Homer (1997)