The cast and some extras attended a medical boot camp to train for the show.
The reason why Jesse is called Mama is revealed in Season 2 Episode 5
Cress Williams and Tommy Dewey both had minor roles on another medical drama: Grey's Anatomy (2005).
Leading actors Rob Lowe and Marcia Gay Harden both had leading roles in films released in the Fall of 2013 to commemorate the 50th anniversary assassination of President John F. Kennedy on November 22, 1963. Lowe played the title role in Killing Kennedy (2013) and Harden played Parkland Hospital trauma nurse Doris Nelson in Parkland (2013).