- Drea's father was a furniture manufacturer and her mother was a playwright. She was raised in Queens primarily by her grandmother and a Nicaraguan nanny. She now takes care of her nanny, who had a heart transplant.
- Her character on Los Soprano (1999) was originally written for only one episode. When she first read for the pilot episode, she was scheduled to play Christopher Moltisanti's girlfriend and thought the series was going to be about opera singers, as she hadn't yet been given a script.
- Speaks fluent Italian and Spanish.
- Gave birth to her 2nd child at age 39, a son Waylon Albert Jennings on April 7, 2011. Child's father is her now ex-fiancé, Shooter Jennings.
- Was in a relationship with Shooter Jennings from 2001 to 2013 and they also were previous engaged 2009-2013. They have 2 children together.
- Gave birth to her 1st child at age 35, a daughter Alabama Gypsy Rose Jennings on November 28, 2007. Child's father is her boyfriend (now ex-fiancé), Shooter Jennings.
- Lost her apartment home of 22 years, along with dozens of other residents, when a gas explosion and raging fire destroyed three East Village, Manhattan buildings on March 26, 2015.
- At NYU, she originally intended to study to be a director, but got attention for her acting.
- Paulo Costanzo, who plays her son on Joey (2004), is only five years younger than she is.
- Graduate of NYU's Tisch School of the Arts.
- Has her mother's, father's and grandmother's names tattooed onto her body.
- Has closed her clothing store Filth Mart in Manhattan and is opening one in Los Angeles
- Is of Italian descent
- Close friends with John Barrowman.
- Ranked #33 in Stuff magazine's "102 Sexiest Women in the World" (2002)
- She studied drama at HB Studio in Greenwich Village in New York City.
- Was engaged, in July 2015-2021, to Whitesnake bass guitarist Michael Devin.
- Her name is from the Greek name Andreas, which was derived from andreios "manly, masculine", a derivative of aner "man".
- Endorsed Donald Trump for president in 2024.
- Masacre en la cárcel 13 (2005) opened on her 33rd birthday.
- Waylon Jennings and Jessi Colter are the grandparents of her two children from her relationship with Shooter Jennings.
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