- Mother, with David Carradine, of son Tom Carradine.
- Lived until late 2009 with her then-partner, actor Naveen Andrews from the TV series Lost (2004) , who is 21 years her junior.
- She has one child, a son she named Free. He later changed his name to Tom. His father is David Carradine.
- As of 2007, she is the only woman to be cast twice in a major role in a movie by Martin Scorsese. The two movies are La última tentación de Cristo (1988) and Bertha, ladrona y amante (1972).
- Acted for several years as Barbara Seagull because of a seagull that was accidentally killed during the filming of "Last Summer." At the time, she said she felt she had absorbed the seagull's spirit.
- As of 2014, she has appeared in three films which were nominated for the Best Picture Oscar: Los elegidos (1983), Hannah y sus hermanas (1986), and El cisne negro (2010).
- The first (and, as of 2006, only) performer to win back-to-back acting awards at the Cannes Film Festival.
- She gave the book of La última tentación de Cristo (1988) to Martin Scorsese while filming Bertha, ladrona y amante (1972) with him.
- Was considered for the role of a dangerous obsessive woman in Atracción fatal (1987). She had played a similar role in El mejor (1984), where she stalks and shoots the hero, who loves a good woman played by Glenn Close who, ironically, beat out Hershey for the role in Atracción fatal (1987) in an against-type casting that made her a household name.
- She has appeared in two films selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Los elegidos (1983) and Hoosiers (1986).
- Her five favourite films of all time are El mago de Oz (1939), Ladrones de bicicletas (1948), Dr. Insólito (1964), El toro salvaje (1980), and La balada de Narayama (1983).
- Barbara's father, Arnold Nathan Herzstein, was Ashkenazi Jewish; her paternal grandparents, Samuel Herzstein and Dora E. Sable, were from Shrepkow, Hungary and Russia. Her mother, Melrose E. Moore, was originally from Arkansas and had English and Scots-Irish (Northern Irish) ancestry.
- Met ex-boyfriend Naveen Andrews on the set of Drowning on Dry Land (1999). They were together until late 2009, although they split for a brief time in 2005 during which Naveen fathered a child, Naveen Joshua.
- She shares a birthday with her son's grandfather, John Carradine.
- Was considered to play as Catherine Tramell in Bajos instintos (1992) but turned it down.
- Member of the drill team and pom-pom squad in high school.
- Dated Warren Beatty.
- Daughter of Arnold Herzstein.
- She was born at 10:01 AM - PST.
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