- Younger brother of Paramount Studios president John Goldwyn.
- Son of actress Jennifer Howard and producer Samuel Goldwyn Jr. Grandson of actress Clare Eames and playwright Sidney Howard on his mother's side; grandson of actress Frances Howard and producer Samuel Goldwyn on his father's side.
- In the HBO miniseries De la Tierra a la Luna (1998), he played astronaut Neil Armstrong, first man to walk on the moon. Later, he had the chance to direct Armstrong in a film called A Walk on the Moon (1999), in which Armstrong was a narrator.
- He studied drama at HB Studio in Greenwich Village in New York City.
- His grandfather, filmmaker Samuel Goldwyn, was a friend of Walt Disney. In 1999, Tony Goldwyn voiced the title character Tarzan in the 37th Disney animated feature, Tarzán (1999).
- His grandfathers, Samuel Goldwyn and Sidney Howard, were frequent collaborators for many years. They worked on a total of eight films together: Su gran aventura (1929), Raffles (1930), One Heavenly Night (1930), Arrowsmith (1931), The Greeks Had a Word for Them (1932), and Fuego otoñal (1936).
- Tony's paternal grandfather, who was born in Warsaw, was from a Polish Jewish family. Tony's other ancestry is Irish, English, Scots-Irish (Northern Irish), Scottish, and German.
- Has two daughters, screenwriter Anna Musky-Goldwyn and actor Tess Goldwyn.
- As of 2024, he has appeared in three films that were nominated for the Best Picture Oscar: Ghost, la sombra del amor (1990), Rey Richard: Una Familia Ganadora (2021) and Oppenheimer (2023), with the latter being a winner in the category.
- Had known Norman Lloyd since birth. Tony's parents were Norman's closest and dearest friends.
- With the encouragement of Norman Lloyd, he decided to be an actor.
- Listed as one of 12 "Promising New Actors of 1990" in John Willis's Screen World, Vol. 42. (1990)
- Half-brother of Liz Goldwyn and Peter Goldwyn.
- Attended Brandeis University in Waltham, Massachusetts.
- He won an Obie Award in 1991 for his performance in "The Sum of Us".
- Attended Hamilton College in Clinton, New York.
- Brother-in-law of actress Colleen Camp.
- Uncle of Emily Goldwyn.
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