- Joseph was originally going to play Jack Banning, Robin Williams' son in Hook. El regreso del capitan Garfio (1991), but he was too young for the part. Steven Spielberg went out of his way to the point of changing the script for Parque jurásico (1993) so that Joseph could play Tim.
- In the original 1990 novel of Jurassic Park, Tim was age 11 and Lex was age 8. Steven Spielberg swapped their ages in Parque jurásico (1993) so that Joseph could play Tim.
- Favorite actor is his idol, James Stewart.
- Has been passionate about oldies music, and when he was growing up, his sister teased him for being old-fashioned.
- Favorite movie is ¡Qué bello es vivir! (1946).
- His parents own and operate a dance studio
- Vuelo a la libertad (1992) began filming on Joe's 7th birthday.
- Brother of John Mazzello, also has an older sister, Mary.
- When work began on Inteligencia artificial (2001) in 1993, he was cast as David. That film would end up being directed by his Parque jurásico (1993) director, Steven Spielberg. His encounter with the velociraptors in that film was itself a reference to Stanley Kubrick's film El resplandor (1980).
- He played Richard Attenborough's grandson in Parque jurásico (1993). Attenborough later cast him as Douglas Gresham in Shadowlands (1993), his next film as a director.
- Graduated from USC with a degree in cinema-television (2005)
- Attended Our Lady of Lourdes High School in Poughkeepsie, NY.
- Was put under a contract in 1993 for Wartime Lies, a screenplay based on the novel by Louis Begley, under direction of the late Stanley Kubrick. He was on the contract for two years. The movie was never made. It did however, lead to rumors of him being in Inteligencia artificial (2001).
- Was considered one of the 55 faces of the future by Nylon Magazine's Young Hollywood Issue.
- His father is of three quarters Italian, and one quarter German Jewish, descent. His mother is of Irish, and small amounts of English and Dutch, ancestry.
- A student at the University of Southern California (USC), as a Cinema-Television major [May 2002].
- Raised in Hyde Park, New York.
- Plays John Deacon in Bohemian Rhapsody, la historia de Freddie Mercury (2018) and has a dog named Deacon in The Pacific (2010).
- His hometown of Hyde Park, NY is where Franklin D. Roosevelt used to live.
- He has appeared in two films that have been nominated for the Best Picture Oscar: Red social (2010) and Bohemian Rhapsody, la historia de Freddie Mercury (2018).
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Parque jurásico (1993) and Red social (2010).
- Born on the same date as Maggie Grace.
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