- For her performance in the television series Lines of Fate she received the Golden Eagle Award as Best Television Actress in 2004.
- In March 2014 she signed a letter in support of the controversial 2014 Russian annexation of Crimea. As a result, she was banned from entering Ukraine along with many other Russian artists and entertainers.
- In 1958 she became part of the Mossovet Theatre troupe.
- Between 1952 and 195 she studied at the Omsk Agricultural Institute.
- Daughter Ksenia Khairova is an actress.
- In 1954 she was admitted to the Russian Academy of Theatre Arts, where she graduated in 1958.
- Valentina Talyzina was a Soviet and Russian film and stage actress.
- She was a member of the Communist Party of the Soviet Union in 1964.
- In 2023, she stated her support for the infamous Russian invasion of Ukraine in an interview; during this, she also made several anti-semitic statements.
- Valentina Talyzina had a minor role in the film The Irony of Fate and also dubbed over major character Nadia because her regular actress, Barbara Brylska, had an obvious Polish accent.
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