- Besides acting, she is also a professional singer.
- To prepare for her role as Ma in La Habitacion (2015), she stayed at home for a whole month and went on a strict diet, to get an understanding of what Ma and Jack were going through.
- Has acted since she was seven years old. However, she considered quitting acting several times as she found the film business to be too difficult and was unable to get the roles she wanted. She pursued careers in photography, interior design and animal training, but ultimately decided to stick with acting.
- Suffers from a severe allergy to cats, a condition that plagued her somewhat during the Capitana Marvel (2019) production shoot.
- She is an avid gamer.
- When Larson presented the Best Actor Oscar to Casey Affleck for his work in Manchester junto al mar (2016) at the 2017 Oscars (the previously year's Best Actress always presents the current year's Best Actor awards and vice versa) she politely handed him the award but did not clap or cheer for his win and looked unhappy about it. Larson later confirmed rumors that she was un-celebratory over Affleck's win due to his real life history of sexual harassment accusations and settled lawsuits, telling an interviewer that "what I did on stage speaks for itself" and that she would not discuss the matter any further.
- Is a huge fan of the Super Mario Bros video games.
- She is a big fan of the Metroid game series and has expressed interest in playing the main character Samus Aran in a possible movie adaption.
- She considers herself to be an introvert.
- For her movie "Captain Marvel", she insisted on having ankle-length body-armor as her character's primary costume; according to Larson, "I just couldn't see myself strolling around in a bathing suit for two hours and change" (referring to Carol Danvers's red Kree uniform and black Warbird outfit, both of which bared her legs).
- She has asthma.
- She is a huge fan of Star Wars, so much that she wishes to appear somewhere in the franchise.
- Her first language is French.
- Is one of 14 actresses to have won the Academy Award, BAFTA Award, Critics' Choice Award, Golden Globe Award and SAG Award for the same performance. The others in chronological order are Julia Roberts for Erin Brockovich, una mujer audaz (2000), Renée Zellweger for Regreso a Cold Mountain (2003), Reese Witherspoon for Johnny & June: Pasión y locura (2005), Helen Mirren for La reina (2006), Jennifer Hudson for Soñadoras (2006), Kate Winslet for Una pasión secreta (2008), Mo'Nique for Precious (2009), Natalie Portman for El cisne negro (2010), Octavia Spencer for Historias cruzadas (2011), Anne Hathaway for Los miserables (2012), Cate Blanchett for Jazmín Azul (2013), Patricia Arquette for Boyhood. Momentos de una vida (2014) and Julianne Moore for Siempre Alice (2014).
- First job was performing in sketches on The Tonight Show with Jay Leno (1992). Soon after, was cast in the television series, Schimmel (2000), which was announced in 2000 but never aired, since right before filming, Robert Schimmel was diagnosed with cancer. After being "on hold" for six months, Fox canceled the show.
- Made home movies as a child, casting her cousins and making sets in her garage.
- Became close friends with Shailene Woodley during the filming of El esplendoroso presente (2013). Larson was having dinner at Woodley's rented apartment when she got the call offering her the lead role in Short Term 12 (2013).
- Screen-tested for the role of Sarah Connor in Terminator: Génesis (2015), but didn't get the role because the casting director said they didn't think she could carry a gun; they didn't ask her to hold a gun during the audition.
- In May 2005, she went on tour with Jesse McCartney.
- Auditioned for the role of Penny in La teoría del Big Bang (2007), but was told she was too young for the part.
- She has starred in 4 movies with Samuel L Jackson which include, Kong: Skull Island (2017), Unicorn Store (2017), Captain Marvel (2019), Avengers Endgame (2019). Also meaning they have both been in the Marvel Cinematic Universe and the Monsterverse.
- Sang "Coming Around" in her movie Vecinos al rescate (2006).
- Is a dual citizen of Canada and the US due to her father being French-Canadian.
- Daughter of Heather (Edwards) and Sylvain Desaulniers. Her paternal grandparents were Aurèle Desaulniers and Gabrielle Marie-Therese (Chatelain) Desaulniers (1931-2015), who were French-Canadians from Winnipeg. Her mother's family is based in California. Her mother has English, Swedish, German, Welsh, and Scottish ancestry. Brie's stage surname, "Larson", is after her matrilineal great-grandmother, Elva Josephine Larson.
- (March 2016-January 2019) was engaged to Alex Greenwald after he proposed to her shortly after she won her Academy Award.
- Brie's go-to karaoke song is Usher's "Burn" from the album "Confessions" (2004).
- Her first gig was a commercial parody sketch "Malibu Mudslide Barbie" for The Tonight Show with Jay Leno in late 1996 at age 7. The sketch had her pouring mud on top of Barbie dolls as their heads popped off. She appeared in several more commercial parodies on Leno in the following years, including "Roadkill Easy Bake Oven" in 1998, and in other Leno show sketches, including one playing a girl scout.
- Was the 146th actress to receive an Academy Award; she won the Best Actress Oscar for La Habitacion (2015) at The Oscars (2016).
- Auditioned for the role of Katniss Everdeen in Los juegos del hambre (2012).
- Doesn't like auditioning for horror movies because you have to mime and react a lot.
- Attended the March 2017 ceremony for her Kong. La Isla Calavera (2017) co-star John Goodman when he received his star on the Hollywood Walk of Fame, alongside Jeff Bridges and Tom Hiddleston.
- On July 2, 2020, she started her own YouTube channel.
- Shared the cover of Vanity Fair magazine's 2016 Hollywood issue with, Jane Fonda, Viola Davis, Cate Blanchett, Jennifer Lawrence, Rachel Weisz, Lupita Nyong'o, Charlotte Rampling, Alicia Vikander, Gugu Mbatha-Raw, Helen Mirren, Diane Keaton and Saoirse Ronan. Photographed by Annie Leibovitz.
- After a considerable period of frustration correcting people who consistently mispronounced her birth name "Desaulniers", Brie changed it to Larson after her Kirsten Larson doll that she owned as a youngster.
- She is a big fan of Jennifer Lopez, who inspired her to become an actress after seeing her in the film Selena (1997). When she met Lopez at the Golden Globe Awards 2024, she got so starstruck that she was moved to tears.
- Was in a relationship with Alex Greenwald, vocalist with rock band Phantom Planet, (2013-2019).
- Auditioned for the role Cindy Paulson in Bajo cero (2013). She overacted her audition scene to the point that she scared the casting director.
- Released a pop album "Finally Out of P.E." (2005), which flopped by selling only 3,500 copies. Larson even toured with Jesse McCartney for Teen People's Rock in Shop Tour. Larson performs a cover of the song "Black Sheep" by the band Metric in the film Scott Pilgrim vs. los ex de la chica de sus sueños (2010), but the soundtrack version features the original song by Metric.
- Moved to Los Angeles, California, right before her ninth birthday (1998).
- Auditioned for the role of Carmen Cortez in Mini espías (2001).
- Older sister of Raya Milaine Desaulniers (born January 5, 1993).
- Auditioned for two Disney Channel Original Movies: Patinando con el corazón (1998) and La morada inteligente (1999). In both instances, she lost to the same actress, Katie Volding.
- Auditioned for the role of Casey Newton in Tomorrowland (2015).
- Auditioned for the role of Carol Gerber in Nostalgia Del Pasado (2001).
- Read the book "Hoot" before she had read the screenplay.
- Daughter of Sylvain (born December 15, 1962) and Heather (née Edwards) Desaulniers (born June 18, 1965). Both were born and raised in the state of California.
- Born on a Sunday at 6:41pm-PDT.
- Maternal great granddaughter of James (1911-1949) and Elva (née Larson) Hunt (1915-1997). Both were born and raised in the state of Utah.
- Maternal granddaughter of Bob Edwards (born 1939), born in the state of California, and Bonnie (née Hunt) Merrill (born 1940), born in the state of Utah. They married in 1960 and divorced in 1972.
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