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Tras un fatídico accidente, un asesino se enfrenta a sus jefes, y a sí mismo, en una persecución internacional que insiste en que no es personal.

A trafficker of illegal immigrants is forced to smuggle his family into America by crossing the Arizona/Mexico border, a searing no-man's-land known as "The Devil's Highway". Along the way, he and his family clash with the U.S. Border Patrol, only to realize that they are being hunted by the real monsters that roam the countryside - werewolves.