Terry Jones spent most of the budget on the "Every Sperm Is Sacred" sequence. The rest of the team found out later.
Sensitive to the young actors in the "Every Sperm is Sacred" scene, Sir Michael Palin actually said "those little rubber things on the end of my sock." The word "cock" was dubbed in later.
The Mr Creosote sketch was filmed at Porchester Hall in Queensway. Hundreds of pounds of fake vomit had to be cleaned up on the last day due to a wedding being scheduled hours later.
The kids who sang in the "Every Sperm is Sacred" sketch later said they had no idea what they were singing about.
According to Terry Gilliam, before the Pythons decided to make a sketch movie about the meaning of life, two ideas were considered for the movie. The first was "Monty Python's World War III", with sponsored armies and soldiers wearing military uniforms full of advertisements. Another idea was the Pythons being tried for fraud, accused of making a tax dodge, not a movie. They spend the entire movie trying to prove that they're shooting an adaptation of "Hamlet" in the Caribbean. At the end, they're found guilty and sentenced to death, and each one of them gets to decide how they're going to die. The idea was used in the death sketch, In which Arthur Jarrett chooses to die while being pursued by naked girls.