Joanne Siegel nació el 1 de diciembre de 1917 en Cleveland, Ohio, Estados Unidos. Estuvo casada con Jerry Siegel. Murió el 12 de febrero de 2011 en Santa Mónica, California, EE.UU..
She was hired as a model by Joe Shuster, the comic-book artist who, along with writer Jerry Siegel, was developing the character of Superman. The facial features and hairstyle of Lois Lane were based on her.