The URL myLizzo.com that is seen in the Lizzo commercial redirects to this special's streaming listing on Paramount+. The phone number 1-833-MYLIZZO (or 1-833-695-4996) leads to an audio playback of the Lizzo commercial.
When Randy does Ozempic with the ladies, it mimics when Michael drinks the blood in The Lost Boys (1987), and both have the same song playing.
During the song "Navigate the American Healthcare System" there is a brief representation of a lithograph by Dutch artist M.C. Escher called "Relativiteit" (Relativity) from 1953.
At the end of the song "Navigate the American Healthcare System", Butters ends up floating through the "library shelves" from the film Interstellar (2014).