During early development, John Wells and Noah Wyle originally envisioned the show as more a direct sequel to their previous hit NBC medical drama "ER," which Wells executive produced, wrote and directed from 1994-2009. Wyle would have reprised his role Dr. John Carter. However, they were unable to secure the rights with original series creator Michael Crichton's estate and thus altered the concept and setting to make it more a spiritual sequel instead.
On Valentine's Day, 2025, it was announced that a 2nd season was greenlit.
Patrick Ball's (Dr. Langdon) first lead role. Fresh out of drama school, he only had one credit, a guest spot on Law & Order, to his name when he booked The Pitt.
Ned Brower, who plays Nurse Jesse, has a master's degree in the science of nursing. Following his RN training at UCLA Santa Monica emergency department, Brower took a full time pediatric emergency nurse position at Children's Hospital Los Angeles.
The Pitt takes place in Pittsburgh Pennsylvania however nearly all of the filming took place in Los Angeles California on sound stages. Several cast members did film for a few days in Pittsburgh around September 2024