Showrunner Steven S. DeKnight revealed that multiple seasons of the show have been mapped out and that "about four or five" potential Spartacus spin-offs are also in the works, all depending on whether House of Ashur is a success.
Jackson Gallagher replaces Todd Lasance as Caesar. Lasance played the role in the third season of Spartacus: War of the Damned (2010) but couldn't reprise in this series due to filming conflicts with NCIS: Sydney (2023).