The photo that Maya finds on her Facebook page of her with President Barack Obama and First Lady Michelle Obama is a real photo from the inaugural ball in Washington DC in January 2009 which Jennifer Lopez attended.
The hard-discount store where Maya works was filmed in a Queens Food Bazaar, a 24-hour shop that was not closed for filming.
When addressing the cast and crew upon completion of principal photography, Peter Segal said that the cast and crew of Second Act was his "favourite family" of everyone he's worked with.
When Maya and Ron are dancing at the Christmas party, they end up dancing the tango while having a disgruntled conversation. This nearly mimics the exact same scene from Wedding Planner - verliebt, verlobt, verplant (2001), in which Mary and Eddie also dance the tango.