Most of the lines Joel Moore utters as Hitler are gibberish, with a few exceptions. When the subtitles read "Why is everyone so mean to me?," he declares in German, "I'm such a shitty actor." Instead of singing the titular line "I Don't Want to Rule the World," he keeps singing "I have worms in my penis."
Kristina Klebe and her mother translated the script for "The Diary of Anne Frankenstein" segment into German for all the German-speaking cast members.
In February 2012, the movie wound up in the headlines when a soundtrack for the gay-themed musical segment 'I Was a Teenage Werebear' was released. Director 'Tim Sullivan' found his eBay listings of the album were pulled and finalized sales were canceled because eBay deemed the auctions, which included a still from the film of Sean Paul Lockhart in his underwear, "morally offensive." eBay reps told Sullivan that he could re-list the soundtrack, but only in the pornographic adult-only section of the site.
The original titles for the "Zom-B-Movie" and "I Was a Teenage Werebear" segments were "Zombie Drive-In" and "I Was a Teenage Vampire."
The segment "I Was a Teenage Werebear" was originally going to take place in a high school, but this location was switched to the beach because shooting in a high school proved to be too expensive.