David Cronenberg's first film in thirty-five years not to have his sister Denise Cronenberg serve as costume design. Denise passed away in summer 2020.
Cronenbergs' first original script since eXistenZ (1999). The working title of that film was also 'Crimes of the Future.'
Viggo Mortensen wanted to play the part of Wippet, but David Cronenberg claims he "harassed" him into playing Saul Tenser instead.
The script is largely adapted from an earlier project Cronenberg had written, called "Painkillers," which was in development in 2002 and had Nicolas Cage attached.
Kristen Stewart replaced Natalie Portman in the role of Timlin.