A PlayStation 2 video game, Mai-HiME: Unmei no Keitouju (literally: Family Tree of Fate) was developed by Marvelous Interactive and released in Japan on June 30, 2005. The adventure game follows a storyline different from the anime and manga series. A remake, Mai-Hime - Unmei no Keitouju Shura, was released for the PC.
Two PlayStation Portable fighting games, Mai-HiME Bakuretsu! Fuuka Gakuen Gekitoushi?! and Mai-HiME Senretsu! Shin Fuuka Gakuen Gekitoushi!!, both developed by Sunrise Interactive, were also released.
A parody trailer for a Mai-Hime movie was included in the first DVD of Mai-Otome, with the title Fuuka Wars or The Great Battle of Fuuka with a release date of 20006.
A second manga series titled My-HiME EXA was developed by Sunrise. It was first serialized in Dengeki Daioh in 2010.
An anime spin-off, entitled My-Otome, aired in Japan from October 2005 to March 2006. The series featured some of the same characters from the previous one, but it is set in a far future timeline.