The producers of this film asked the producers of Scary Movie 4 (2006) if they could use their bathroom set for this film as it was an exact replica of the sets used in Saw (2004) and Saw 2 (2005). They were given permission to use it.
The film's most graphic scene - Jigsaw's brain surgery - remained completely uncut by the MPAA. The filmmakers argued that it was no different from what people would see in any medical documentary on TV.
As with the previous two films, only the actors who appeared in the final scene were given the complete script.
Although it appears otherwise, only four prosthetic pigs were used in the "Pig Vat".
Amanda (Shawnee Smith) was not originally supposed to grab Lynn (Bahar Soomekh) by the throat and threaten her in the sick room, as can be seen by her surprised facial expressions in the moments after. The line where Lynn says "you fucking freak" was not written in the script. Bahar added it in after Shawnee unexpectedly threw her against the wall.